This article was originally published here
Diabetes treatment. 2021 May 14th: dc202791. doi: 10.2337 / dc20-2791. Online before printing.
ABSTRACT
OBJECTIVE: The aim of this study was to determine the frequency of newly diagnosed type 1 diabetes without signs of autoimmunity and the respective frequency of ketoacidosis in children, adolescents and young adults during the coronavirus disease 2019 (COVID-19) pandemic in Germany compared to the past decade.
RESEARCH DESIGN AND METHODS: Based on data from the German Diabetes Prospective Follow-up Registry (DPV), we compared data from 715 children, adolescents and young adults who had between 1 new type 1 during the COVID-19 pandemic in Germany – Diabetes was diagnosed in March and June 30, 2020 with data from 5,428 children, adolescents and young adults over the same period from 2011 to 2019. Adjusted differences and relative risks (RRs) of negative β-cell autoantibody test results and diabetic ketoacidosis were determined using a multivariable protocol estimated -binomial regression analysis. An upper non-inferiority test (margin 1%) was used to assess whether the autoantibody negativity rate in 2020 was not higher than that in 2011 to 2019.
RESULTS: The estimated frequencies of autoantibody negativity in 2020 and 2011-2019 were 6.6% (95% CI 5.1-8.4) and 7.2% (95% CI 6.5-8.0), respectively. with an absolute difference of -0.68% (90%) CI -2.07 to 0.71; P upper non-inferiority = 0.023). The increase in the estimated incidence of diabetic ketoacidosis during the COVID-19 pandemic was similar between autoantibody negative and positive type 1 diabetes (adjusted RRs 1.28) [95% CI 0.80-2.05] and 1.57 [1.41-1.75], respectively).
CONCLUSIONS: This study found no evidence that the COVID-19 pandemic resulted in a significantly increased number of new cases of autoantibody-negative type 1 diabetes in children, adolescents and young adults. In addition, autoantibody-negative type 1 diabetes showed no particular susceptibility to ketoacidosis either before or during the pandemic.
PMID: 33990377 | DOI: 10.2337 / dc20-2791
