According to a new study, women under the age of 55 with type 2 diabetes are at higher risk of developing coronary artery disease. The study shows that women younger than 55 years old with type 2 diabetes had a ten-fold higher risk of coronary artery disease over the next two decades, with lipoprotein insulin resistance (LPIR) proving to be a powerful, predictive biomarker proved good.
“Unfortunately, we’re seeing younger and younger people with heart attacks,” said co-author Samia Mora, associate professor at Harvard Medical School in the United States. “When a younger person has a cardiovascular event, it affects their future quality of life, productivity and contribution to society,” added Mora.
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For the study, published in the journal JAMA Cardiology, the researchers analyzed more than 50 risk factors in 28,024 women who participated in the ten-year study. The team analyzed approximately 50 biomarkers related to cardiovascular health.
Commonly used metrics like low density lipoprotein (LDL) cholesterol (or “bad” cholesterol) and hemoglobin A1C (a measure of blood sugar levels) had much weaker associations with the occurrence of coronary artery disease in women under 55 than LPIR, a more recent one Insulin resistance metric.
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LPIR uses a weighted combination of six lipoprotein measurements and is analyzed by special laboratory tests. While LDL cholesterol was only associated with a 40 percent increase in the risk of developing coronary artery disease in women under the age of 55, LPIR showed a six-fold (600 percent) increase.
“Diabetes is largely preventable, but it is a system-wide problem and we urgently need to continue searching for new strategies to address it,” said Mora.
“These could be innovative lifestyle-based strategies such as community efforts, greater public health efforts, pathways to medical targeting of metabolic pathways, or new surgical approaches,” noted Mora. (IANS)