COVID-19 is more than just a respiratory disease. New evidence shows that COVID-19 acts as a vascular disease and helps explain why diabetics are at increased risk of becoming seriously ill, according to a new university study.
Florida Institute of Technology PhD student Amanda Almeida de Oliveira, faculty member in Biomedicine and Chemical Engineering and Science Kenya Pedrosa Nunez, Complete the “Crosstalk of TLR4, Vascular NADPH Oxidase, and COVID-19 in Diabetes: What Are the Potential Effects?” Review Form. The manuscript was published in the May issue of Vascular Pharmakology.
In a paper, De Oliveira and Nunez examined the potential effects of COVID-19 on diabetics. They identified severe inflammation in COVID-19 patients that was associated with overactivation of the immune system. Has. Given the presence of inflammation, they suggested that oxidative stress also contributes to the severity of COVID-19. This is because the mechanisms that cause inflammation and oxidative stress overlap. The two researchers are even more convinced that COVID-19 is not the only respiratory disease, given previous studies that have pointed to the disease’s vascular connections and studies of problems that patients have had throughout the body. Did.
“Heart problems can occur, the kidneys and in severe cases, systemic dysfunction,” said De Oliveira. “When you started discussing COVID-19 as a vascular disease, it all made sense because blood vessels connect all systems in the human body.”
de Oliveira and Nunes also examined how toll-like receptors 4 (TLR4), cofactor NADPH, diabetes and COVID-19 interact. They observed altered levels / activities of both TLR4 and NADPH oxidase in diabetes and, at work, these mechanisms, together or independently, in severe diabetes-related COVID-19. He said he could play a role. TLR4 is a human protein that plays an important role in the regulation of NF-κB, an important transcription factor that regulates genes involved in both innate and adaptive immune responses. There is also a link between TLR4 and NADPH oxidase, which has been reported to regulate NF-NFB activation and may contribute to inflammation, oxidative stress, and the severity of COVID-19 in diabetics.
Research into diseases that stalled the planet over the past year has posed a number of challenges to researchers, including De Oliveira and Nunez. You’ve learned a lot over the past year, but indicated that researchers are still trying to understand a lot about the disease, including the long-term effects of COVID-19 on diabetics. As the study is still very new, Nunes also mentioned the opportunity for researchers to continue to contribute to better understanding the various aspects of the effects of COVID-19 on the vasculature.
“Look, COVID-19 can affect this too. That needs to be investigated, ”says our contribution in connection with this disease. “Everyone tries to contribute by saying, ‘I’ve seen that in my background and I’ve never seen that in literature,’ and that’s the idea. . “
Through this study, Nunes indicated that COVID-19 is more serious than ever. With vaccines too, this problem is a real problem that needs to be resolved. In the case of De Oliveira and Nunez, the public needs to be prepared in case this happens again.
“Careful, I think it’s a word,” said Nunez. “We’re trying to get back to normal life, but we still have to take care of everyone. It’s not in normal mode yet. We will, but be careful. “
Source Link COVID-19, Diabetes Research Raises Evidence of Vascular Disease
