Ethnic variety helps determine extra genomic areas related to diabetes-related traits

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By including multiethnic participants large-scale genetic studies have identified more regions of the genome that are associated with type 2 diabetes characteristics than when the studies were carried out exclusively to Europeans.

The international MAGIC collaboration consists of more than 400 global scientists and carried out a genome-wide meta-analysis under the direction of the University of Exeter. The results published in Nature Genetics show that expanding research into various ancestors will not only benefit more and better results, but ultimately benefit global patient care. ..

Almost 87 percent so far. This type of genome research is carried out by Europeans. This means that the way these results are implemented may not be of optimal benefit to people of non-European descent.

The team analyzed data from a variety of cohorts. Diabetes .. Researchers have studied the glycemic properties used to diagnose diabetes and monitor blood sugar and insulin levels.

Researchers have integrated 30% of the total cohort in people from East Asia, Hispanics, African American, Southern Asia, and Sub-Saharan Africa. In doing so, they discovered 24 loci or genome regions that are associated with glycemic properties, as if the study was carried out exclusively on Europeans.

Professor Ines Barroso from the University of Exeter, who led the study, said: “Type 2 diabetes is a growing global health problem, with most of the biggest increases outside Europe occur. Genetic Factors Our research between different countries and cultures teaches us that they differ in the way we need to understand them. It is important to ensure that we can provide a precise approach to diabetes management that streamlines treatment and care for everyone. “

Dr. Ji Chen, the lead author of the University of Exeter, said: “By including an ethnically diverse cohort than if we were to limit our work on Europeans, we have discovered 24 additional regions of the genome. Beyond morality, we ensure that research reflects the world’s population. Our work shows that this approach leads to better results. “

The team found that not all loci were discovered in all ancestors, but they were still useful in providing information about that ancestor’s glycemic properties. The co-author Cassandra Spracklen, an assistant professor at the University of Massachusetts Amherst, said: ancestors do not work well with people from different backgrounds together. This is important as healthcare moves to a more accurate approach. Failure to take into account genetic variations through ancestors affects the ability to accurately diagnose diabetes. “

This study, titled “Genome Architecture Beyond The Ancestors of Glycemic Properties”, Natural Genetics.

A new genetic marker for type 2 diabetes identified in East Asians

For more informations:
Genome architecture beyond the ancestors of glycemic properties, Nature Genetics (2021). DOI: 10.1038 / s41588-021-00852-9, www.nature.com/articles/s41588-021-00852-9

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University of Exeter

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Ethnic diversity helps identify more genomic regions associated with diabetes-related traits

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