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Yoo J, et al. Summary OS-1101. Presented at: the International Liver Congress; 23-26 June (virtual meeting).
Disclosure:
Yoo does not report any relevant financial information. Please refer to the study for all other authors relevant financial information.
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Glucose variability was an independent predictor of hepatocellular carcinoma, according to a study presented at the International Liver Congress.
“Diabetes mellitus is a major risk factor for developing HCC. Several studies have reported that diabetes increases the risk of HCC by 2.4 to 4 times. However, there are no studies that have examined exactly which metabolic parameters can be used to estimate the risk of HCC in diabetics. ” Jeong-Ju Yoo, SoonChunHyang University School of Medicine said. “Lately, glucose variability (GV) has attracted attention in diabetics alongside traditional tools like HbA1c as a prognostic tool.”
In a nationwide, population-based cohort study, by the end of 2017, researchers tracked 674,178 patients with diabetes who had more than three health exams to investigate the association between GV and HCC in patients with diabetes. During a median follow-up of 6.7 years, they identified 5,494 cases of HCC; Patients with basal blood glucose levels of 180 mg / dL or more had the highest risk of HCC (adjusted HR = 1.19; 95% CI 1.08-1.31). In addition, the researchers identified a linear relationship between increases in GV and HCC prevalence, with the risk of HCC increasing by 27% (aHR = 1.27; 95% CI, 1.17-1.38) for the highest GV -Quartile increased compared to the lowest GV quartile.
“We found that GV is an independent predictor of HCC. Even after considering possible disruptive factors, there was a linear relationship between the increase in GV and the risk of HCC, ”concluded Yoo. “The results were consistent for different GV evaluation methods and different sensitivity analyzes.”
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