TUESDAY, March 23, 2021 (HealthDay News) – Type 2 diabetes mellitus (T2DM) is associated with an increased risk of Parkinson’s disease (PD) as well as faster PD progression, according to an overview published online on March 8 in Movement.
Harneek Chohan of Queen Mary University in London and colleagues conducted a systematic literature review to identify studies examining the association of T2DM with PD risk and PD progression. Summary data from genome-wide association studies were then used to examine the causal effects of genetic liability to T2DM on PD risk and PD progression.
The researchers found that pooled effect estimates showed that T2DM was associated with an increased risk of PD (odds ratio, 1.21), and there was some evidence that T2DM was associated with faster progression of motor symptoms (standardized mean difference, 0.55) and a cognitive decline (standardized mean difference, -0.92). Using Mendelian randomization, there was supportive evidence of a causal effect of diabetes on PD risk (inverse variance-weighted method ratio, 1.08) and some evidence of an effect on motor progression (inverse variance-weighted method ratio, 1.10 ). However, there was no evidence of an association with cognitive progression.
“Careful screening for T2DM and early treatment for T2DM in PD patients may be advisable,” the authors write.
Two authors disclosed financial ties to the pharmaceutical and biotechnology industries.
Abstract / full text