Metabolic penalties of weight problems and sort 2 diabetes: balancing genes and setting for customized care


This article was originally published here

Cell. 2021, February 27: S0092-8674 (21) 00162-8. doi: 10.1016 / j.cell.2021.02.012. Online before printing.


The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to continue to increase, driven by the growing aging sedentary population. The burden on global health care is expected to be enormous. This review explores the latest work and emerging ideas regarding genetic and environmental factors that affect metabolism. Translational research and clinical applications, including the effects of the COVID-19 pandemic, are highlighted. Looking ahead, strategies to personalize all aspects of prevention, management and care are needed to improve health outcomes and reduce the impact of these metabolic disorders.

PMID: 33675692 | DOI: 10.1016 / j.cell.2021.02.012