NSAIDs could increase threat of kidney harm in sufferers with diabetes – Medical Every day Information


People with diabetes may be particularly susceptible to acute kidney injury when taking nonsteroidal anti-inflammatory drugs. This emerges from new research presented at the American Society of Nephrology’s Kidney Week 2020 Reimagined virtual conference.

Short-term use of NSAIDs, which include aspirin, ibuprofen (like Advil), and naproxen (like Aleve), has been linked to kidney damage and hyperkalemia (high levels of potassium), according to Dr. Cynthia C. Lim and colleagues from Singapore General Hospital.

The researchers tracked a cohort of more than 3,800 hospital patients who were prescribed new drugs. If participants received NSAIDs for more than 14 days, they were 65% more likely to have acute kidney disease or high potassium levels within 30 days. In addition, prescribing an NSAID together with a diuretic or an inhibitor of the renin-angiotensin-aldosterone system was significantly associated with a four-fold increased likelihood of kidney damage or hyperkalemia.

Adjusted results showed that patients with cardiovascular disease, RAASi consumption, diuretic consumption, and increased potassium at the start of the study had a 41%, 42%, 91% and 36% increased risk of acute kidney injury and a high potassium finding, respectively had.


Diabetes Diabetes Care Kidney Disease