medwireNews: A maternal history of diabetes is linked to accelerated loss of glycemic control and an increased risk of adverse outcomes in adolescents with type 2 diabetes, an analysis of data from the TODAY study suggests.
As reported in the virtual 81st scientific meetings of the ADA, children and adolescents aged 10–17 years with type 2 diabetes who had mothers (n = 177), fathers (n = 72) or both parents (n = 79) with diabetes had significantly higher mean values of glycated hemoglobin (HbA1c) at the start of the study than those without a history of diabetes (n = 158) with 6.1%, 6.0% and 6.2% compared to 5.8 % (43, 42 and 44 vs. 40 mmol.) / Mol).
During an average follow-up of 10.2 years, participants with a maternal history of diabetes during or after pregnancy were significantly 60% more likely than those with loss of glycemic control – defined as HbA1c over 8% for more than 6 months – than those none, with cumulative incidence rates of 87 and 88% versus 80%. However, there were no such associations with paternal diabetes.
Rachana Shah (Children’s Hospital of Philadelphia, Pennsylvania, USA) and team also found that participants with a history of maternal but not paternal diabetes had a significantly increased likelihood of kidney hyperfiltration and “unfavorable vascular indices.” including greater heart rate variability.
The speaker concluded that more research is needed to understand “the mechanisms of prenatal exposure” […] with the ultimate goal of preventing adverse effects. “
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Scientific meetings of the ADA; 25-29 June 2021
