Potential breakthrough in understanding diabetes | science | information

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DRStudy Years published Monday in Nature Connections diabetes researcher André Marette fed groups of mice the exact same diet, but by changing the type of proteins they ate: some (besides fat and sugar) ate only one protein called casein, which is found in milk, while others were given a protein blend similar to the “normal” human diet.

The result: in mice that were given a “low-calorie” diet, the type of protein ingested did not change much in terms of weight, but in mice with a richer diet, a varied diet was associated with an increased intake. 15% heavier weight after 12 weeks with the “casein only” diet.

In addition, Mr. Maret explains: “The insulin levels were also different. [ndlr : les protéines variées favorisaient plus le diabète] The gaps were large. And microbes even after just two weeks [les bactéries qui vivent dans nos intestins] It has been altered so that the type of protein you eat has an impact. (…) Normally the body mobilizes the fat reserves in the end, but due to the change in the type of protein in our mice, there seemed to be a blockage in the liver. [qui nuisait à la remobilisation des réserves de graisse]».

Marit says this discovery has a twofold meaning. At first it was thought that types of protein did not affect weight gain or diabetes, but it seems we need to rethink this idea. Then it could change the way we breed laboratory mice, especially the ones we use to study obesity and diabetes. At the moment almost everyone is fed casein only – but if the diabetes prevents them altogether, this could falsify the data.

Note that researchers from Duke University (USA), Gothenburg (Sweden), and Copenhagen (Denmark) also contributed to the article.

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